595 papers
This study utilizes single-nucleus gene expression and eQTL analyses of the human retina, RPE, and choroid to demonstrate that specific AMD-risk variants alter gene expression in distinct cell types and reveal age-related declines in complement inhibitors within the choriocapillaris.
This study benchmarks three simple DNA staining-based image metrics for live-cell chromatin tracking, demonstrating that the newly introduced Diffuse Signal Index (DSI) offers superior sensitivity in distinguishing chromatin reorganization during NETosis compared to the coefficient of variation and 1-Gini, while all three correlate with chromatin accessibility.
This study reveals that the substrate diacylglycerol (DAG) promotes DGAT1 oligomerization and drives its localization to curved ER tubules, thereby modulating the enzyme's activity and subcellular distribution during triglyceride synthesis.
This study identifies small-molecule modulators that inhibit AHR, DOT1L, or GSK3 to dramatically enhance the efficiency and cytotoxic function of stroma-free, hiPSC-derived T cells, thereby establishing a robust strategy for scalable universal and autologous T cell therapies.
This study demonstrates that supplementing bull semen extenders with a low concentration (1%) of sustainably obtained blueberry extract significantly improves the post-thawing motility and quality of cryopreserved spermatozoa, offering a sustainable approach to enhancing reproductive outcomes in artificial insemination.
This study demonstrates that long-term mechanical confinement drives monocyte-to-macrophage differentiation across multiple cell types by activating the KDM6B enzyme to demethylate H3K27me3, thereby derepressing macrophage-specific transcriptional programs and enhancing phagocytic capacity.
This study reveals that chromosome condensation mechanically primes the nucleus for mitosis by increasing nuclear envelope tension, a process dependent on SUN proteins that facilitates cyclin B1 translocation and dynein loading to ensure timely mitotic entry and prevent segregation errors.
This study combines GlycoSHIELD computational modeling and DNA-PAINT super-resolution microscopy to demonstrate that N-glycosylation of the Na,K-ATPase β1 subunit promotes stable nanoscale clustering via a galectin-lattice mechanism rather than steric repulsion.
This study utilizes longitudinal single-nucleus profiling and lineage tracing to identify a transient PAX8+ intermediate mesoderm niche that supports early human myogenesis through BMP7-laminin signaling and SIX1-EYA3 cofactor switching, thereby defining the intrinsic and extrinsic mechanisms governing the PAX3-to-PAX7 progenitor transition.
This study validates SERPINB2 as a robust, cross-platform chondrogenic biomarker and reveals a coordinated activation of the SERPIN network during cartilage lineage commitment, highlighting its potential role in regulating the chondro-osteogenic decision and its utility for osteoarthritis monitoring.
This study identifies Rab12 as a novel negative regulator of mitophagy and mitochondrial homeostasis, demonstrating that its depletion enhances the clearance of damaged mitochondria and links vesicular trafficking machinery to mitochondrial quality control with potential implications for neurodegenerative diseases.
This study demonstrates that extracellular vesicles derived from small airway epithelial cells and fibroblasts in COPD patients carry distinct microRNA signatures enriched in pathways driving cellular senescence and fibrosis, suggesting their critical role in disease progression.
This study identifies 17 proteins localizing to the complex feeding and flagellar apparatus of the marine heterotrophic flagellate *Diplonema papillatum*, including novel components like Mad2 and MBP65, thereby establishing a molecular foundation for understanding nutrient acquisition mechanisms in this abundant group of plankton.
This study identifies the ER-resident protein MOSPD2 as a selective recruiter of the cholesterol transporter STARD3 at ER-late endosome/lysosome contact sites, establishing their specific interaction as a unique functional unit essential for maintaining lysosomal dynamics and cholesterol homeostasis.
This study reveals that denatured serum albumin, induced by physiological conditions like alcohol intake or oxidative stress, binds to platelet integrin IIb3 to regulate activation, adhesion, and aggregation as effectively as fibrinogen, thereby identifying a previously unrecognized mechanism for thrombotic risk.
This study demonstrates that VeritaCell-derived autologous skin cell suspensions significantly accelerate wound healing and reduce scarring-associated thickening in a rat model, validating their efficacy even at low donor-to-wound ratios and suggesting a promising strategy for treating extensive injuries like burns while minimizing donor skin requirements.
This study reveals that importin-beta (Impβ), traditionally known for mediating nucleocytoplasmic transport, directly regulates actin polymerization and stress fiber formation to control cell migration and tissue integrity, a function distinct from its canonical transport role.
This study reveals that SMN deficiency in Spinal Muscular Atrophy drives extensive, tissue-specific proteomic remodeling across multiple organs, with partial SMN restoration via antisense oligonucleotides only incompletely reversing these molecular alterations, particularly in metabolic and mitochondrial pathways.
This study demonstrates that PARP16 protects against cardiac hypertrophy and heart failure by ADP-ribosylating and inhibiting the transcriptional activity of NFAT1, a mechanism whose loss leads to pathological cardiac remodeling.
This study demonstrates that inducible deletion of endothelial KLF4 in mice recapitulates the key clinical features of preeclampsia, including gestational hypertension and fetal growth restriction, thereby providing a novel model that links upstream cardiovascular risk factors to the disease's underlying mechanisms.